The Respiratory System and Breathing: KS3 Biology Guide

The respiratory system brings oxygen into the body and removes carbon dioxide. In humans, this system centres on the lungs and involves a precise set of organs working together to move air in and out and exchange gases across a thin, moist surface. This process is a core topic in KS3 biology, typically taught in Year 8.

What are the main organs of the respiratory system?

The journey of air from the outside world to your bloodstream passes through several key structures:

Organ / Structure | Role
Nose / mouth | Entry point; nose warms, filters, and moistens incoming air
Trachea (windpipe) | Carries air from the throat towards the lungs; kept open by C-shaped rings of cartilage
Bronchi | Two tubes (one per lung) that branch off the trachea
Bronchioles | Smaller branches of the bronchi that spread throughout each lung
Alveoli | Tiny air sacs at the ends of bronchioles; the site of gas exchange
Diaphragm | Dome-shaped muscle below the lungs that drives breathing movements
Intercostal muscles | Muscles between the ribs that assist breathing

Together, these structures form a branching tree — wide at the top (trachea) and enormously detailed at the ends (around 300 million alveoli in an adult human).

How does breathing work — inhalation and exhalation?

Breathing is a mechanical process driven by changes in air pressure inside the chest (thorax). The diaphragm and intercostal muscles create those pressure changes.

Inhalation (breathing in)

The diaphragm contracts and flattens downwards.

The external intercostal muscles contract, pulling the rib cage upwards and outwards.

The volume of the thorax increases.

Pressure inside the lungs falls below atmospheric pressure.

Air rushes in from outside to equalise pressure.

Exhalation (breathing out)

The diaphragm relaxes and returns to its dome shape.

The intercostal muscles relax; the rib cage falls inwards and downwards.

Thorax volume decreases.

Pressure inside the lungs rises above atmospheric pressure.

Air is pushed out.

This cycle repeats around 12–20 times per minute at rest for a healthy adult (NHS data, 2024). During vigorous exercise that rate can rise above 40 breaths per minute.

What is gas exchange and where does it happen?

Gas exchange is the movement of oxygen from the air into the blood, and carbon dioxide from the blood into the air. It happens in the alveoli.

Why are alveoli so well suited to gas exchange?

The alveoli have four key adaptations:

Large surface area — hundreds of millions of alveoli give a total surface area of roughly 70 m² in an adult (about the size of one side of a tennis court).

Thin walls — alveolar walls are just one cell thick, so gases only have a short distance to diffuse.

Moist lining — gases dissolve in the moisture, allowing diffusion across the membrane.

Rich blood supply — each alveolus is surrounded by a dense network of capillaries, maintaining a steep concentration gradient for both oxygen and carbon dioxide.

The concentration gradient

Gas exchange works by diffusion — movement from high concentration to low concentration.

Gas | In alveolar air | In blood arriving at lungs | Direction of diffusion
Oxygen (O₂) | High | Low | Alveolus → blood
Carbon dioxide (CO₂) | Low | High | Blood → alveolus

Once oxygen diffuses into the blood, it binds to haemoglobin in red blood cells and is carried to every cell in the body. Carbon dioxide dissolves in plasma and is carried back to the lungs.

How do breathing and respiration differ?

A very common confusion at KS3: breathing (ventilation) is the physical movement of air in and out of the lungs. Respiration is the chemical reaction inside cells that releases energy from glucose using oxygen. One is mechanical; the other is biochemical. You breathe so that your cells can respire.

Worked example: tracing a molecule of oxygen

Question: Describe the journey of one oxygen molecule from outside the body to a muscle cell in the thigh.

Answer:

Oxygen enters through the nose (or mouth) and is warmed and moistened.

It travels down the trachea, then into the left or right bronchus.

It moves through progressively smaller bronchioles.

It reaches an alveolus, where it dissolves in the moist lining.

It diffuses across the thin alveolar wall and the capillary wall into the blood.

It binds to haemoglobin in a red blood cell.

The red blood cell travels via the pulmonary vein to the heart, then out through the aorta.

It is pumped through arteries and arterioles to the capillaries surrounding a muscle cell in the thigh.

Oxygen diffuses from the blood into the muscle cell (concentration in the cell is low because respiration uses it up continuously).

The Department for Education's Science Programmes of Study for Key Stage 3 requires pupils to understand the structure and function of the gas exchange system and the mechanism of breathing. BBC Bitesize KS3 Biology covers the respiratory system and gas exchange with labelled diagrams, animations, and exam-style questions (see bbc.co.uk/bitesize/subjects/z9ddmp3).

Frequently asked questions

What is the difference between breathing and respiration?

Breathing (also called ventilation) is the physical process of moving air into and out of the lungs using the diaphragm and intercostal muscles. Respiration is the chemical process that occurs inside every cell, where glucose reacts with oxygen to release energy, producing carbon dioxide and water as waste products. You breathe so that your cells have a constant supply of oxygen for respiration and can get rid of carbon dioxide. Students sometimes use the words interchangeably, but in biology they describe two completely different processes.

Why do alveoli have such a large total surface area?

Each individual alveolus is tiny — about 0.2 mm in diameter — but because there are approximately 300 million of them in a pair of adult lungs, the combined surface area is enormous (around 70 m²). This large surface area maximises the rate of diffusion: more surface area means more molecules can cross the membrane at any one moment. This is why conditions that damage the alveoli, such as emphysema (often caused by long-term smoking), severely reduce the ability to absorb oxygen — the loss of surface area makes gas exchange far less efficient.

What do the C-shaped rings of cartilage in the trachea do?

The trachea contains 15–20 C-shaped rings of cartilage arranged along its length. Cartilage is a firm, flexible tissue that holds the trachea open so that air can flow freely even when surrounding muscles contract. The rings are C-shaped (not complete circles) because the open part faces the oesophagus (gullet) at the back, allowing the oesophagus to bulge slightly into that space when you swallow a large mouthful of food.

How does exercise affect breathing rate?

During exercise, your muscle cells respire faster to release more energy, producing more carbon dioxide. Rising CO₂ levels in the blood are detected by receptors in the brain (specifically the medulla oblongata) and in the main arteries. Nerve signals increase both the rate and depth of breathing — you take more breaths per minute and each breath is deeper. This brings in more oxygen and removes CO₂ faster. At rest, a typical 14-year-old breathes around 15–20 times per minute; during vigorous sport this can exceed 40–50 breaths per minute.

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